邪恶力量第十季将解决迪恩死去和魔化的问题，这也说明迪恩将再次复活，而卡西迪奥即将耗尽的力量将会成为重要的剧情。迪恩也不是唯一一个处于险境的自由意志三人组成员。残存不多力量的卡西迪奥正在用最后的荣光和时间赛跑。
Brother's Keeper 哥哥的守护者
Dean失踪了，Sam和Castiel著急的要找他，但在这时Rowena翻译出了「诅咒之书」中解除「该隐标记」的三种材料，Castiel召唤了Crowley希望他可以帮忙寻找这三种材料。而Dean在处理一件有关吸血鬼的案子时，因为「该隐标记」的关系而害死了他的好朋友Rudy，故而Dean受不了内心的愧疚，Dean召唤了Death，希望Death…
The Prisoner 囚徒
Dean很生气因为Sam请Charlie去帮忙破解「诅咒之书」却害死了Charlie，所以和Sam吵了起来，并要求Sam停止对「诅咒之书」的研究。之後，Dean决定一个人踏上为Charlie报仇的路，他找到了斯戴恩家族位於路易斯安那州的庄园，并一个人杀了进去，但Dean没有看到杀害Charlie的凶手，在Dean的拷问下才得知原来有另一队人前去了…
Dark Dynasty 黑暗王朝
Sam请求Charlie和Castiel一起与Rowena共同翻译「诅咒之书」以便能尽快得知解除「该隐标记」的方法。Dean发现了一个案子，凶手挖了死者的眼睛并从三楼跳下逃跑，所以和Sam一起去探查後发现原来是斯戴恩家族的人作的，并且斯戴恩家族的人还跟踪Dean，却反被Dean捉住。而Dean从他口中问出了原来斯戴恩家族只是一个邪恶且古老家…
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