公元2035年，总部位于芝加哥的美国USR公司开发出超能机器人产品--NS-5，其外形酷似人类，拥有强化耐久的钛金属外壳，可执行各种任务。从保母、厨师、快递、遛狗到管理家庭收支，简直是无所不能。一时间，机器人的数量成3倍趋势增长，平均每5人便拥有1个机器人。随着NS-5被大量倾销，机器人开始充当起社会各个领域的重要角色。而发明它的USR公司也成为地球上有史以来最强大的集团。
警探史普纳(威尔·史密斯Will Smith饰)始终留恋以往简单的生活，爱听老歌，喜欢老式的打扮。他厌恶科技和机器人，却又不得不生活在由这两者组成的世界里。专门从事机器人心理研究的科学家苏珊(布里吉特·莫伊纳罕Bridget Moynahan饰)向来崇尚逻辑与科学，她坚信总有一天机器人会胜过人类，并回过头来帮助人类进步。
生活观念南辕北辙的史普纳和苏珊却在调查一桩疑似NS-5谋杀人类的案件中不期而遇……人类制造机器人时，通常会遵循所谓“机器人三大安全法则”来设计并控制它们。但是，随着调查的深入，人们发觉机器人似乎已经学会了自我思考，并且解开了控制他们的密码，成为了完全独立的“机器类”。
人类必须开始重新思考如何面对机器人，但是，机器人或者人类自身都值得信赖吗？
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