该片讲述了一对闺蜜的故事，当她们一个打算建立家庭，而另一个患上了癌症，她们的友谊遭受了极大考验。米莉(托妮·科莱特)和杰西(德鲁·巴里摩尔)打小一起长大，她们彼此之间没有秘密，几乎所有东西都可以分享。直到她们都长成了大人，这种友谊也没有改编。米莉事业有成，和丈夫、两个孩子生活在美丽的别墅里。
而杰西成了一名城市规划者，和男友雅戈住在伦敦运河上的船屋上，过着波西米亚式的生活。两人依旧是一对无话不谈的好闺蜜。然而直到杰西竭尽全力地想要怀上一个孩子，而米莉发现自己患上了乳房癌，两个人的关系出现了裂痕。她们不再无话不谈。有些事情即使和对方也无法分享。
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