影片开场，巴尼（西尔维斯特·史泰龙 饰）带领敢死队的老伙计克里斯马斯（杰森·斯坦森 饰）、贡纳（杜夫·龙格尔 饰）等人驾驶直升机劫持火车，救出了被囚禁的用刀高手医生（韦斯利·斯奈普斯 饰）。
经过短暂的休整，他们奔赴索马里潜入某倒卖军火组织的老巢中执行任务，谁知巴尼发现该组织老大竟然是当年本该死去的敢...死队战友康拉德·斯通班克斯（梅尔·吉布森 饰）。一番激烈的交火过后，斯通班克斯成功逃脱，而敢死队方面则损失惨重。
此役过后，不仅军方和敢死队藏着一股怒火，连斯通班克斯也被彻底激怒，最强的硬汉迎来生死对决。
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