以唐代女皇武则天时期为大背景，唐朝美容圣手男医贺兰钧在太医院以把宫中众女塑造成花容月貌为人生乐趣。贺兰钧出众的医术遭贱人嫉妒眼红，被人陷害，屋漏偏逢连夜雨，贺兰钧发现自己的孩子却不是亲生的，而是妻子雪姬和别人生的孩子。贺兰钧被妻子抛弃，走投无路，流落街头。被有情有义以得到他为终身目标的结婚狂青楼女子...苏莲衣所收留。落魄的贺兰钧并没有因为一些列的变故而堕落。他利用自己的智慧和医术让不少有情人终成眷属。贺兰钧还不计前嫌，帮助一直作恶多端的裴云天 得到自己的真命天女，使他改邪归正。在经历了诸多惊险之后，贺兰钧意识到心灵美才是真的美，而心地善良对爱情忠贞不渝一直陪伴在自己身边的苏莲衣才是真善美的化身，最终两人终成眷属。
袁天师成功求到雨水，贺兰钧认定袁天师是闯运气求到雨水，袁天师为了向众人证明自己的能耐来到殿外求仙桃。一个弟子顺着一根木杆爬到半空摘下一只大仙桃，武则天等人一脸惊讶意识到袁天师确实有几分神通，袁天师求到仙桃盘问弟子求桃过程，弟子跪在地上将私自摘下仙桃未请示仙人的经过说了一遍，袁天师勃然大怒指责弟子私…
画师悄悄带走苏莲衣，苏莲衣从昏迷中苏醒过来跟画师谈话，画师向苏莲衣讲述混入武家的原因，当年武崇安去世武府的一些女仆跟着一起陪葬，其中一个女仆便是画师的妹妹，画师因为妹妹无辜丢掉性命对武家的人怀恨在心。苏莲衣听完画师的话终于明白武崇安的魂魄根本没有显灵，一切都是画师在幕后搞鬼。 贺兰钧与武三思找到画…
武崇安母亲思儿心切想为亡儿举办冥婚，苏莲衣成为武母心仪的冥婚对象，为了逼迫苏莲衣跟死去的武崇安举办冥婚，武母装神弄鬼吓唬苏莲衣，苏莲衣惶恐不安以为武崇安的亡魂真的显灵。贺兰钧哭笑不得安慰开导苏莲衣。 房间时面已经点燃了迷香，贺兰钧闻到迷香的时候已经晚了，苏莲衣与贺兰钧一起被送到武母面前，武母要求苏…
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