胡八一（靳东饰）上山下乡来到中蒙边境的岗岗营子，带上了家中仅存的一本书——《十六字阴阳风水秘术》，闲来无事将书中文字背得滚瓜烂熟。之后参军到西藏，遇上雪崩掉落一条巨大的地沟当中，胡八一利用自己懂得的墓葬秘术逃得不死。复员后，胡八一和好友王胖子（赵达饰）一起加入了一支前往新疆考古的考古队。一行人历经万险来到了塔克拉玛干沙漠中的精绝古城遗址，进入了地下“鬼洞”。洞中机关重重、陷阱不断，这神秘的鬼洞似乎在一位先知的掌控之中。
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画上还说先知预测四人中的一人会打开石匣子，正在王胖子偏不信邪之时，一直昏迷的陈教授突然大叫一声妖怪便蹦了起来，疯癫之状及其可怕，另一边，躺在地上的叶亦心抽搐着醒来，原本就虚弱的她挣扎了几下竟然就这样死去了。这时疯疯癫癫的陈教授竟然扑到了石匣子上，用力推开了石盖。安抚好陈教授，王胖子发现这先知的预测…
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